Epigenetic Regulation of Glucose Transporter 4 by Estrogen Receptor β
نویسندگان
چکیده
منابع مشابه
Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells.
Estrogen replacement therapy and other unopposed estrogen treatments increase the incidence of endometrial abnormalities, including cancer. However, this effect is counteracted by the co-administration of progesterone. In the endometrium, glucose transporter (GLUT) expression and glucose transport are known to fluctuate throughout the menstrual cycle. Here, we determined the effect of estrogen ...
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Transport of glucose across the plasma membrane by GLUT-4 and subsequent phosphorylation of glucose by hexokinase II (HKII) constitute the first two steps of glucose utilization in skeletal muscle. This study was undertaken to determine whether epinephrine and/or insulin regulates in vivo GLUT-4 and HKII gene transcription in rat skeletal muscle. In the first experiment, adrenodemedullated male...
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Strategies to amplify whole-body glucose disposal are key therapies to treat type 2 diabetes. Mice that over-express glucose transporter 4 (Glut4) in skeletal muscle, heart, and adipose tissue (G4Tg) exhibit increased fasting glucose disposal and thus lowered blood glucose. Intriguingly, G4Tg mice also exhibit improved insulin-stimulated suppression of endogenous glucose production even though ...
متن کاملexpression of glucose transporter 4 (glut4) is increased by cinnamaldehyde in c2c12 mouse muscle cells
background: in diabetes mellitus because of the absence or insufficient sensitivity to insulin, glucose transporter protein in cell membrane, glucose transporter 4, is decreased. glut4 is the major glucose transporter in skeletal muscle and adipose tissue, which is under control of insulin. it remains, however, unclear whether cinnamaldehyde plays a regulatory role(s) or not. objectives: the ob...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2011
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2011-1054